77th ASSH Annual Meeting - Back to Basics: Practice and Education-IC37: Back to the Future: Translational Techniques That Will Change Peripheral Nerve Repair (AM22)

Video Transcription

Video Summary

Peripheral nerve repair techniques were discussed in a panel discussion moderated by David Brogan. The session included presentations by Dr. Adam Reid on peripheral nerve injury and repair, Dr. Amy Moore on electrical stimulation for nerve generation, and Dr. Susan Isaacs on a novel repair technique called nerve tape. Dr. Reid discussed the epidemiology of nerve injury and the importance of understanding changes in the neuronal cell body and repair site. Dr. Moore presented on the use of electrical stimulation, showing that it can accelerate nerve growth and improve regeneration. Dr. Isaacs introduced nerve tape as a novel repair technique that aims to provide support and protection to injured nerves. The session highlighted the need for translational techniques to improve peripheral nerve repair and the potential of electrical stimulation and nerve tape in this regard.<br /><br />Another topic discussed was the molecule SARM1, which is involved in nerve degeneration after injury. When there is nerve damage, the disruption of the enzyme NMNAT leads to an increase in NMN and triggers the degeneration process. Inhibiting SARM1 can prolong the stable phase before degeneration. Two approaches being explored are PEG fusion, which involves using polyethylene glycol to prevent degeneration, and SARM1 inhibition, which aims to extend the stable phase and prevent degeneration. Early studies have shown promising results in animal models and some human cases. Challenges include the inhibitory effect of myelin and the need for molecular machinery for nerve regeneration. More research is needed to fully understand and validate these approaches, but they offer exciting possibilities for improving nerve repair outcomes.

Meta Tag

Session Tracks Microsurgery

Session Tracks Nerve

Speaker Adam Reid

Speaker Amy M. Moore, MD

Speaker Jaimie T. Shores, MD

Speaker Jonathan E. Isaacs, MD

Speaker Steve K. Lee, MD

Keywords

peripheral nerve repair techniques

electrical stimulation

nerve tape

nerve injury

nerve regeneration

SARM1 molecule

NMNAT enzyme

degeneration process

inhibiting SARM1

PEG fusion

molecular machinery